Introduction:
Cialis 40mg x 50
- Generic Name: Tadalafil 2.5mg
- Dosage Form: Film-coated tablet
- Drug Class: Impotence agents (to treat erectile dysfunction)
What is Cialis?
Cialis is a brand name for the drug tadalafil, belonging to a class of medications known as phosphodiesterase type 5 (PDE5) inhibitors. It is used to treat erectile dysfunction (impotence) and symptoms of benign prostatic hypertrophy.
Recommended Dosage:
The dose of CIALIS varies for each individual as prescribed by the doctor.
- For erectile dysfunction: The recommended dose is 10 mg taken 30 minutes before sexual activity. The dose can be adjusted to 20 mg or reduced to 5 mg based on individual response and tolerability.
- For the treatment of BPH: The recommended dose is 5 mg once daily.
How to Take It: Cialis 40mg x 50
Cialis can be taken with or without food as food does not affect its action or absorption.
- Swallow the tablet whole. Do not crush or split it.
- When used to treat impotence or ED, the ability to have intercourse is improved for up to 36 hours after taking the tablet.
Mechanism of Action: Cialis 40mg x 50
Cialis works by vasodilating blood vessels and arteries and relaxing smooth muscles, which increases blood flow to the penis, leading to an erection. This process is mediated by Nitric oxide, which is released from nerve endings and endothelial cells of blood vessels, stimulating the synthesis of cGMP in smooth muscle cells, resulting in relaxation and increased blood flow. Tadalafil inhibits PDE5, which is responsible for the decrease in cGMP.
Uses: Cialis 40mg x 50
Cialis is used for the following purposes:
- Erectile dysfunction treatment
- Symptoms of enlarged prostate (Benign prostatic hyperplasia)
- Pulmonary Arterial Hypertension (PAH): a disease in which blood pressure is increased in pulmonary capillaries and arteries.
Side Effects: Cialis 40mg x 50
Side effects from Cialis are usually mild and well-tolerated. Common side effects include:
- Headache
- Flushing
- Runny nose
- Indigestion
- Effects on the vasculature of the head and neck
Other side effects may include back pain and muscle aches, which usually subside within a couple of days. In rare cases, a prolonged and painful erection lasting longer than four hours may occur.
Contraindications: Cialis 40mg x 50
Cialis should not be used in the following cases:
- Nitrates: Concomitant use with nitrates can cause a sudden drop in blood pressure.
- Hypersensitivity Reactions: Patients with known allergies or hypersensitivity to Cialis should not consume the drug since it may lead to serious complications such as rashes, angioedema, redness, ataxia, etc.
- Concomitant Guanylate Cyclase (GC) Stimulators: Do not use Cialis in patients who are using a GC stimulator, such as riociguat, as it can cause a massive drop in blood pressure.
- Hereditary Eye Disorders: Certain hereditary eye disorders, such as retinitis pigmentosa, may be exacerbated by Cialis, leading to vision problems.
Drug Interactions: Cialis 40mg x 50
Cialis may interact with the following drugs:
- Nitrates: Both nitrates and Cialis cause hypotension and vasodilation of blood vessels.
- Alpha-Blockers: Both drugs cause a drop in blood pressure.
- Alcohol: Both alcohol and tadalafil (a PDE5 inhibitor) act as mild vasodilators.
- Antibiotics and Antifungals: Some antibiotics and antifungal medications can alter the way Cialis is metabolized.
- HIV Medications: Protease inhibitors and non-nucleoside reverse transcriptase inhibitors used to treat HIV can interfere with Cialis metabolism and lead to increased side effects.
- Antacids: Reduce the rate of absorption of tadalafil.
- Cytochrome P450 Inhibitors.
- Grapefruit Juice: Can inhibit the breakdown of Cialis in the body, leading to increased drug levels.
Storage: Cialis 40mg x 50
Store Cialis at 25°C (77°F); excursions permitted to 15-30°C. Keep out of reach of children.
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