DES 1-3 1MG.

Insulin-Like Growth Factor-1 DES 1 – 3, is one of the most popular polypeptides. It is more effective when compared to IGF-1 LR3 and burns more fat. It generates new muscle cells and thereby affects muscle growth enormously. 

IGF-1 DES (1-3) is a truncated variant of the conventional IGF-1 with a so-called tri-peptide structure. Due to the alteration in its structure, IGF-1 DES (1-3) is 10 times more formidable than IGF-1 in the overgrowth and proliferation of so-called satellite cells in muscle  and other tissues. 

WHAT IS IGF-1?

The Insulin-like Growth Factor (IGF-1) is a homologue of the endocrine hormones produced in the liver. Its quantity increases under the influence of human growth factor/hormone. This growth factor promotes cell division and general growth of cells.. This is very important for the development of bones during childhood and throughout life.

BENEFITS OF IGF-1

• It promotes Protein synthesis in the body
• Liberation of energy from fat stores, which leads to a considerable amount of fat loss while maintaining lean body mass.
• Increases revitalization of body’s nerve tissues
• Upregulates antioxidant benefit and ligament strength
• Enhances hyperplasia in muscle cells, which leads to increased muscle mass.
• Improved cognitive function

CHANGES IN WEIGHT DURING IGF-1 THERAPY:-

 All your weight gain will be caused by actual muscle growth, which is a long-term effect.

Steroids cause weight gain which is basically water weight and often lead to various side effects. But by using this, you will acquire solid muscle gain after every one or two weeks, composed of actual heavy muscle.

The body of a person who is on steroids goes through hypertrophy; this means that they will only be increasing the size of the existing cells in their muscles whereas IGF-1 leads to hyperplasia, which promotes the growth and expansion of new developing muscle cells.

VARIANTS OF IGF-1

There are two groups of IGF variants:- IGF-1 LR3 and DES IGF-1

IGF-1 LR3

IGF -1 is a naturally occurring protein of the body which plays an important role in growth of muscles and increasing muscle mass but has a shorter half life . Thus, a better and a long lasting version of it has been created which is IGF-1 LR3 . It works more effectively as compared to its natural form and has a longer plasma half life in the body. 

 It also causes burning of fat by inhibiting movement of glucose into cells, and utilizing  fat for production of energy.

It is not ideal for targeted muscle development that does not require site injections. It cycles through the whole body, binding to muscle receptors, and stays active for about a day. 

IGF-1 DES

Another type of IGF-1 called DES IGF-1 is approximately ten times more effective than regular IGF-1. Both these variants possess a similar structure but their mechanism of action is different.

DES IGF-1 can be used in Target muscle development cases as it is effective only at the site of injection as it doesn’t cycle throughout the body and possess a shorter half life.

DES IGF-1 can also bind to receptors  affected by lactic acid which is its uniqueness .This allows it to signal tissue growth even during training. 

IGF-1 VARIANT DOSING 

IGF-1

Daily for a week.

Best results if taken after a workout 

Desensitization is rarely observed.

IGF-1 LR3

Daily for a week. 

Desensitization occurs. 

A break is needed before resuming treatment. 

SIDE EFFECTS OF IGF-1

Most common side effects it produces is hypoglycemia that is a drop in body sugar level below to what is required or needed.

This drop is more severe if caused by insulin.

It is believed that it may increase tumor size in cancer patients but does not cause cancer.